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1

gPKPDSim: a SimBiology®-based GUI application for PKPD modeling in drug development

Hosseini, Iraj, Gajjala, Anita, Bumbaca Yadav, Daniela, Sukumaran, Siddharth, Ramanujan, Saroja, Paxson, Ricardo, Gadkar, Kapil

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2018

Language:

english

File:

PDF, 2.23 MB

english, 2018

2

Pharmacokinetics of protein and peptide conjugates

Bumbaca, Brandon, Li, Zhe, Shah, Dhaval K.

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2018

Language:

english

File:

PDF, 513 KB

english, 2018

3

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain

Gadkar, Kapil, Yadav, Daniela Bumbaca, Zuchero, Joy Yu, Couch, Jessica A., Kanodia, Jitendra, Kenrick, Margaret K., Atwal, Jasvinder K., Dennis, Mark S., Prabhu, Saileta, Watts, Ryan J., Joseph, Sean

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2016

Language:

english

File:

PDF, 2.15 MB

english, 2016

4

Compartmental Tissue Distribution of Antibody Therapeutics: Experimental Approaches and Interpretations

Boswell, C. Andrew, Bumbaca, Daniela, Fielder, Paul J., Khawli, Leslie A.

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 319 KB

english, 2012

5

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

Ruihuan Chen, Merry C. Nishimura, Stephanie M. Bumbaca, Samir Kharbanda, William F. Forrest, Ian M. Kasman, Joan M. Greve, Robert H. Soriano, Laurie L. Gilmour, Celina Sanchez Rivers, Zora Modrusan, S

Journal:

Year:

2010

Language:

english

File:

PDF, 2.60 MB

english, 2010

6

Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics

Bumbaca, Daniela, Boswell, C. Andrew, Fielder, Paul J., Khawli, Leslie A.

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 224 KB

english, 2012

7

Enhanced Tumor Retention of a Radiohalogen Label for Site-Specific Modification of Antibodies

Boswell, C. Andrew, Marik, Jan, Elowson, Michael J., Reyes, Noe A., Ulufatu, Sheila, Bumbaca, Daniela, Yip, Victor, Mundo, Eduardo E., Majidy, Nicholas, Van Hoy, Marjie, Goriparthi, Saritha N., Trias,

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.62 MB

english, 2013

8

Vascular Physiology and Protein Disposition in a Preclinical Model of Neurodegeneration

Boswell, C. Andrew, Mundo, Eduardo E., Johnstone, Bernadette, Ulufatu, Sheila, Schweiger, Michelle G., Bumbaca, Daniela, Fielder, Paul J., Prabhu, Saileta, Khawli, Leslie A.

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 1007 KB

english, 2013

9

Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats

Boswell, C. Andrew, Mundo, Eduardo E., Zhang, Crystal, Bumbaca, Daniela, Valle, Nicole R., Kozak, Katherine R., Fourie, Aimee, Chuh, Josefa, Koppada, Neelima, Saad, Ola, Gill, Herman, Shen, Ben-Quan,

Journal:

Bioconjugate Chemistry

Year:

2011

Language:

english

File:

PDF, 3.68 MB

english, 2011

10

Real-Time Correction Of Three-Dimensional Nonlinearities For A Laser Rangefinder

Bumbaca, Federico

Journal:

Optical Engineering

Year:

1986

Language:

english

File:

PDF, 2.62 MB

english, 1986

11

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

Zuchero, Y. Joy Yu, Chen, Xiaocheng, Bien-Ly, Nga, Bumbaca, Daniela, Tong, Raymond K., Gao, Xiaoying, Zhang, Shuo, Hoyte, Kwame, Luk, Wilman, Huntley, Melanie A., Phu, Lilian, Tan, Christine, Kallop,

Journal:

Year:

2015

Language:

english

File:

PDF, 2.51 MB

english, 2015

12

SAE Technical Paper Series [SAE International SAE 2014 World Congress & Exhibition - (APR. 08, 2014)] SAE Technical Paper Series - EV Customer Usage Measurement Program for Durability Test Mode Development

Bumbaca, Valerie Earlene

Year:

2014

Language:

english

File:

PDF, 1.61 MB

english, 2014

13

Nonclinical Toxicology and Biocompatibility Program Supporting Clinical Development and Registration of the Port Delivery System With Ranibizumab for Neovascular Age-Related Macular Degeneration

Bantseev, Vladimir, Horvath, Joshua, Barteselli, Giulio, Ranade, Shrirang, Maia, Mauricio, Yadav, Daniela Bumbaca, Schuetz, Chris, Shelton, Amy, Booler, Helen S.

Journal:

Toxicologic Pathology

Year:

2020

File:

PDF, 341 KB

2020

14

A practical approach to image restoration for computer vision

Federico Bumbaca, Kenneth C Smith

Journal:

Computer Vision, Graphics, and Image Processing

Year:

1988

Language:

english

File:

PDF, 91 KB

english, 1988

15

A practical approach to image restoration for computer vision

Federico Bumbaca, Kenneth C. Smith

Journal:

Computer Vision, Graphics, and Image Processing

Year:

1988

Language:

english

File:

PDF, 2.00 MB

english, 1988

16

Intelligent computer-assisted instruction: a theoretical framework

Federico Bumbaca

Journal:

International Journal of Man-Machine Studies

Year:

1988

Language:

english

File:

PDF, 1.74 MB

english, 1988

17

Design and implementation of a colour vision model for computer vision applications

Federico Bumbaca, Kenneth C. Smith

Journal:

Computer Vision, Graphics, and Image Processing

Year:

1987

Language:

english

File:

PDF, 835 KB

english, 1987

18

Genome-based identification and characterization of a putative mucin-binding protein from the surface of Streptococcus pneumoniae

Daniela Bumbaca, James E. Littlejohn, Hannah Nayakanti, Alexander H. Lucas, Daniel J. Rigden, Michael Y. Galperin, Mark J. Jedrzejas

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 703 KB

english, 2007

19

Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice

Daniela Bumbaca, Hong Xiang, C Andrew Boswell, Ruediger E Port, Shannon L Stainton, Eduardo E Mundo, Sheila Ulufatu, Anil Bagri, Frank-Peter Theil, Paul J Fielder, Leslie A Khawli, Ben-Quan Shen

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.76 MB

english, 2012

20

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

Bien-Ly, N., Yu, Y. J., Bumbaca, D., Elstrott, J., Boswell, C. A., Zhang, Y., Luk, W., Lu, Y., Dennis, M. S., Weimer, R. M., Chung, I., Watts, R. J.

Journal:

Journal of Experimental Medicine

Year:

2014

Language:

english

File:

PDF, 3.41 MB

english, 2014

21

Comparative Physiology of Mice and Rats: Radiometric Measurement of Vascular Parameters in Rodent Tissues

Boswell, C. Andrew, Mundo, Eduardo E., Ulufatu, Sheila, Bumbaca, Daniela, Cahaya, Hendry S., Majidy, Nicholas, Van Hoy, Marjie, Schweiger, Michelle G., Fielder, Paul J., Prabhu, Saileta, Khawli, Lesli

Journal:

Molecular Pharmaceutics

Year:

2014

Language:

english

File:

PDF, 2.09 MB

english, 2014

22

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

Yadav, Mahesh, Jhunjhunwala, Suchit, Phung, Qui T., Lupardus, Patrick, Tanguay, Joshua, Bumbaca, Stephanie, Franci, Christian, Cheung, Tommy K., Fritsche, Jens, Weinschenk, Toni, Modrusan, Zora, Mellm

Journal:

Year:

2014

Language:

english

File:

PDF, 3.24 MB

english, 2014

23

Sequence Analysis and Characterization of a Novel Fibronectin-Binding Repeat Domain from the Surface of Streptococcus pneumoniae

Bumbaca, Daniela, LittleJohn, James E., Nayakanti, Hannah, Rigden, Daniel J., Galperin, Michael Y., Jedrzejas, Mark J.

Journal:

Omics A Journal of Integrative Biology

Year:

2004

Language:

english

File:

PDF, 544 KB

english, 2004

24

Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1)

Uppal, H., Doudement, E., Mahapatra, K., Darbonne, W. C., Bumbaca, D., Shen, B.-Q., Du, X., Saad, O., Bowles, K., Olsen, S., Lewis Phillips, G. D., Hartley, D., Sliwkowski, M. X., Girish, S., Dambach,

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 927 KB

english, 2015

25

Quantitative cumulative biodistribution of antibodies in mice

Yip, Victor, Palma, Enzo, Tesar, Devin B, Mundo, Eduardo E, Bumbaca, Daniela, Torres, Elizabeth K, Reyes, Noe A, Shen, Ben Q, Fielder, Paul J, Prabhu, Saileta, Khawli, Leslie A, Boswell, C Andrew

Journal:

Year:

2014

Language:

english

File:

PDF, 754 KB

english, 2014

26

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

Yu, Y. J., Atwal, J. K., Zhang, Y., Tong, R. K., Wildsmith, K. R., Tan, C., Bien-Ly, N., Hersom, M., Maloney, J. A., Meilandt, W. J., Bumbaca, D., Gadkar, K., Hoyte, K., Luk, W., Lu, Y., Ernst, J. A.,

Journal:

Science Translational Medicine

Year:

2014

Language:

english

File:

PDF, 642 KB

english, 2014

27

Structure of a protein-DNA complex essential for DNA protection in spores of Bacillus species

Lee, K. S., Bumbaca, D., Kosman, J., Setlow, P., Jedrzejas, M. J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 1.07 MB

english, 2008

28

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

Zheng, Yanan, Tesar, Devin B., Benincosa, Lisa, Birnböck, Herbert, Boswell, C. Andrew, Bumbaca, Daniela, Cowan, Kyra J, Danilenko, Dimitry M., Daugherty, Ann L., Fielder, Paul J., Grimm, Hans Peter, J

Journal:

Year:

2012

Language:

english

File:

PDF, 1.18 MB

english, 2012

29

A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

Kinnunen, Hanne M., Sharma, Vikas, Contreras-Rojas, Luis Rodrigo, Yu, Yafei, Alleman, Chlöe, Sreedhara, Alavattam, Fischer, Stefan, Khawli, Leslie, Yohe, Stefan T., Bumbaca, Daniela, Patapoff, Thomas

Journal:

Journal of Controlled Release

Year:

2015

Language:

english

File:

PDF, 1.12 MB

english, 2015

30

A case study on Sema3E-Fc aggregation and assay-dependent differences in quantitation

Bumbaca, Daniela, Tong, Raymond K, Koch, Alexander W, Xiang, Hong, DeForge, Laura E, Shen, Ben-Quan, Lu, Yanmei

Journal:

Year:

2012

Language:

english

File:

PDF, 1.51 MB

english, 2012

31

A strategy for risk mitigation of antibodies with fast clearance

Hötzel, Isidro, Theil, Frank-Peter, Bernstein, Lisa J., Prabhu, Saileta, Deng, Rong, Quintana, Leah, Lutman, Jeff, Sibia, Renuka, Chan, Pamela, Bumbaca, Daniela, Fielder, Paul, Carter, Paul J., Kelley

Journal:

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

32

Catabolic Fate and Pharmacokinetic Characterization of Trastuzumab Emtansine (T-DM1): an Emphasis on Preclinical and Clinical Catabolism

Shen, Ben-Quan, Bumbaca, Daniela, Saad, Ola, Yue, Qin, V. Pastuskovas, Cinthia, Cyrus Khojasteh, S., Tibbitts, Jay, Kaur, Surinder, Wang, Bei, Chu, Yu-Waye, M. LoRusso, Patricia, Girish, Sandhya

Journal:

Current Drug Metabolism

Year:

2012

Language:

english

File:

PDF, 647 KB

english, 2012

33

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

Kamath, Amrita V, Yip, Victor, Gupta, Priyanka, Boswell, C Andrew, Bumbaca, Daniela, Haughney, Peter, Castro, Joni, Tsai, Siao Ping, Pacheco, Glenn, Ross, Sarajane, Yan, Minhong, Damico-Beyer, Lisa A,

Journal:

Year:

2014

Language:

english

File:

PDF, 889 KB

english, 2014

34

Evaluating the use of antibody variable region (Fv) charge as a risk assessment tool for predicting typical cynomolgus monkey pharmacokinetics

Bumbaca Yadav, Daniela, Sharma, Vikas K., Boswell, Charles A., Hotzel, Isidro, Tesar, Devin, Shang, Yonglei, Ying, Yong, Fischer, Saloumeh K., Grogan, Jane L., Chiang, Eugene Y., Urban, Konnie, Ulufat

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 2.09 MB

english, 2015

35

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4

Bumbaca, Daniela, Wong, Anne, Drake, Elizabeth, Reyes II, Arthur E., Lin, Benjamin C., Stephan, Jean-Philippe, Desnoyers, Luc, Shen, Ben-Quan, Dennis, Mark S.

Journal:

Year:

2011

Language:

english

File:

PDF, 4.72 MB

english, 2011

36

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor

Deng, Rong, Bumbaca, Daniela, Pastuskovas, Cinthia V., Boswell, C. Andrew, West, David, Cowan, Kyra J., Chiu, Henry, McBride, Jacqueline, Johnson, Clarissa, Xin, Yan, Koeppen, Hartmut, Leabman, Maya,

Journal:

Year:

2016

Language:

english

File:

PDF, 1.86 MB

english, 2016

37

WIDESPREAD BRAIN DISTRIBUTION AND ROBUST BACE1 INHIBITION FOLLOWING INTRACEREBROVENTRICULAR INFUSION OF ANTI-BACE1 IN NON-HUMAN PRIMATES

Bumbaca, Daniela, Bumbaca, Daniela, Wildsmith, Kristin, Fuji, Reina, Scearce-Levie, Kimberly, Maloney, Janice, Meilandt, William, Solanoy, Hilda, Lu, Yanmei, Peng, Kate, Wilson, Blair, Chan, Pamela, K

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 57 KB

english, 2014

38

Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain

Kanodia, JS, Gadkar, K, Bumbaca, D, Zhang, Y, Tong, RK, Luk, W, Hoyte, K, Lu, Y, Wildsmith, KR, Couch, JA, Watts, RJ, Dennis, MS, Ernst, JA, Scearce-Levie, K, Atwal, JK, Ramanujan, S, Joseph, S

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Year:

2016

Language:

english

File:

PDF, 513 KB

english, 2016

39

Widespread brain distribution and activity following anti-BACE1 intracerebroventricular infusion in nonhuman primates

Bumbaca Yadav, Daniela, Maloney, Janice A, Wildsmith, Kristin R, Fuji, Reina N, Meilandt, William J, Solanoy, Hilda, Lu, Yanmei, Peng, Kun, Wilson, Blair, Chan, Pamela, Gadkar, Kapil, Kosky, Andrew, G

Journal:

British Journal of Pharmacology

Year:

2017

Language:

english

File:

PDF, 812 KB

english, 2017

40

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

Bown, Hanne Kinnunen, Bonn, Catherine, Yohe, Stefan, Yadav, Daniela Bumbaca, Patapoff, Thomas W., Daugherty, Ann, Mrsny, Randall J.

Journal:

Journal of Controlled Release

Year:

2018

Language:

english

File:

PDF, 710 KB

english, 2018

41

Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells

Li, Guangmin, Guo, Jun, Shen, Ben-Quan, Bumbaca Yadav, Daniela, Sliwkowski, Mark X., Crocker, Lisa M., Lacap, Jennifer A., Lewis Phillips, Gail D

Journal:

Molecular Cancer Therapeutics

Year:

2018

Language:

english

File:

PDF, 1.57 MB

english, 2018

42

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow

Boswell, C. Andrew, Ferl, Gregory Z., Mundo, Eduardo E., Bumbaca, Daniela, Schweiger, Michelle G., Theil, Frank-Peter, Fielder, Paul J., Khawli, Leslie A., Gelovani, Juri

Journal:

Year:

2011

Language:

english

File:

PDF, 1011 KB

english, 2011

43

Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategies

Bumbaca, Brandon, Li, Wei

Journal:

Acta Pharmaceutica Sinica B

Year:

2018

Language:

english

File:

PDF, 1.27 MB

english, 2018

44

Distributed Markov Chain Monte Carlo for Bayesian Hierarchical Models

Bumbaca, Federico, Misra, Sanjog, Rossi, Peter E.

Journal:

SSRN Electronic Journal

Year:

2017

File:

PDF, 2.19 MB

2017

45

Evaluation and use of an anti‐cynomolgus monkey CD79b surrogate antibody‐drug conjugate to enable clinical development of polatuzumab vedotin

Li, Dongwei, Lee, Donna, Dere, Randall C., Zheng, Bing, Yu, Shang‐Fan, Fuh, Franklin K., Kozak, Katherine R., Chung, Shan, Daniela, Bumbaca Yadav, Nazzal, Denise, Danilenko, Dimitry, Go, Mary Ann T.,

Journal:

British Journal of Pharmacology

Year:

2019

Language:

english

File:

PDF, 779 KB

english, 2019

46

Complex formation of antiâVEGFâC with VEGFâC released during blood coagulation resulted in an artifact in its serum pharmacokinetics

Bumbaca Yadav, Daniela, Reyes, Arthur E., Gupta, Priyanka, Vernes, JeanâMichel, Meng, Y. Gloria, Schweiger, Michelle G., Stainton, Shannon L., Fuh, Germaine, Fielder, Paul J., Kamath, Amrita V., She

Journal:

Pharmacology Research & Perspectives

Year:

2020

File:

PDF, 1.55 MB

2020

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